Procedure
|
What
|
Proposal
|
In Vitro Fertilisation (IVF) with or without Intracytoplasmic Sperm Injection
(ICSI)
|
A full cycle of IVF treatment, with or without intracytoplasmic sperm injection (ICSI), should comprise 1 episode of ovarian stimulation and the transfer of any resultant fresh and frozen embryo(s). This will include the storage of any frozen embryos for 1 year following egg collection. Patients should be advised at the start of treatment that this is the level of service available on the NHS and following this period continued storage will need to be funded by themselves or allowed to perish.
An embryo transfer is from egg retrievalto transfer to the uterus. The fresh embryo transfer would constitute one such transfer and each subsequent transfer to the uterus of frozen embryos would constitute another transfer.
Before a new fresh cycle of IVF can be initiated any previously frozen embryo(s) must be utilised.
Where couples have previously self-funded a cycle then the couples must utilise the previously frozen embryos, rather than undergo ovarian stimulation, egg retrieval and fertilisation again.
|
For anyone who has progressed to IVF the CCG is proposing that they will fund the current cycle with a cycle being considered as:
• One fresh and up to one frozen transfer
* Where more embryos are frozen than can be used for the proposed cycle/s patients can choose to fund storage themselves.
|
Frozen Embryo Transfer
|
For women less than 37 years of age only one embryo or blastocyst to be transferred in the first cycle of IVF and for subsequent cycles only one embryo/blastocyst to be transferred unless no top quality embryo/blastocyst available then no more than 2 embryos to be transferred.
For women age 37-39 years only one embryo/blastocyst to be transferred unless no top quality embryo/blastocyst available then no more than 2 embryos to be transferred.
For women 40-42 years consider double embryo transfer.
A fresh cycle would be considered completed with the attempt to collect eggs and transfer of a fresh embryo.
|
For those who have previously had CCG funding and have embryos in storage the CCG is proposing:
* Where more embryos are frozen than can be used for the proposed cycle/s patients can choose to fund storage themselves.
|
Embryo/Bloastocyst Freezing and Storage
|
|
Where embryos have previously been stored the CCG is proposing:
|
Surgical Sperm Recovery
(Testicular Epididymal Sperm Aspiration
(TESA)/Percutaneous Sperm Aspiration
(PESA) including storage where required)
|
|
Where this is part of a current cycle the proposal is that:
* Patients can choose to fund sperm storage themselves beyond the NHS funded period.
|
Intrauterine Insemination (IUI) unstimulated
|
NICE guidelines state that unstimulated intrauterine insemination as a treatment option in the following groups as an alternative to vaginal sexual intercourse:
-
people who are unable to, or would find it very difficult to, have vaginal intercourse because of a clinically diagnosed physical disability or psychosexual problem who are using partner or donor sperm
Due to poor clinical evidence, a maximum of 6 cycles of IUI (as a replacement for IVF/ICSI and without donor sperm).
|
The CCG proposal is that:
|
Donor Oocyte Cycle
|
The patient may be able to provide an egg donor; alternatively the patient can be placed on the waiting list, until an altruistic donor becomes available. If either of the couple exceeds the age criteria prior to a donor egg becoming available, they will no longer be eligible for treatment.
This will be available to women who have undergone premature ovarian failure (amenorrhoea >6 months and a raised FSH >25) due to an identifiable pathological or iatrogenic cause before the age of 40 years or to avoid transmission of inherited disorders to a child where the couple meet the other eligibility criteria.
|
The CCG proposal is that:
* Patients can choose to fund oocyte / embryo / blastocyst storage themselves.
|
Donor Sperm Insemination
|
The use of donor insemination is considered effective in managing fertility problems associated with the following conditions:
-
severe deficits in semen quality in couples who do not wish to undergo ICSI
-
Infectious disease of the male partner (such as HIV)
-
Severe rhesus isoimmunisation
-
Where there is a high risk of transmitting a genetic disorder to the offspring
Donor insemination is funded up to a maximum of 6 cycles of Intrauterine Insemination (IUI).
|
The CCG proposal is that:
• the patient is able to donate sperm for the current cycle of:
• IUI
• IVF
* Patients can choose to fund sperm storage themselves beyond the NHS funded period.
|
Egg Storage for Patients Undergoing Treatments
Sperm Storage for Patients Undergoing Treatments
|
When considering and using cryopreservation for people before starting chemotherapy or radiotherapy that is likely to affect their fertility, follow recommendations in ‘The effects of cancer treatment on reproductive functions’ (2007).
When using cryopreservation to preserve fertility in people diagnosed with cancer, use sperm, embryos or oocyctes.
Offer sperm cryopreservation to men and adolescent boys who are preparing for medical treatment for cancer that is likely to make them infertile.
Local protocols should exist to ensure that health professionals are aware of the values of semen cryostorage in these circumstances, so that they deal with the situation sensitively and effectively.
Offer oocyte or embryo cryopreservation as appropriate to women of reproductive age (including adolescent girls) who are preparing for medical treatment for cancer that is likely to make them infertile if:
-
they are well enough to undergo ovarian stimulation and egg collection and
-
this will not worsen their condition and
-
enough time is available before the start of their cancer treatment.
Cryopreserved material may be stored for an initial period of 10 years.
Following cancer treatment, couples seeking fertility treatment must meet the defined eligibility criteria.
|
The CCG proposal is that they fund storage of eggs/sperm that have been frozen already for those undergoing treatment for cancer and other medical conditions that affect their reproductive functions.
The CCG will fund the storage until the person reaches the age of 42 or for 10 years (whichever comes first).
If the patient dies whilst their sperm or eggs are in storage the CCG will no longer fund the storage 3 months from the person dying.
* Patients can choose to fund storage themselves beyond the NHS funded period.
|